CURRICULUM VITAE

DR. AHMED AL-HARRASI

 

 

BSc, Chemistry (SQU), MSc, Organic Chemistry (FUB, Berlin), PhD, Organic Chemistry (FUB, Berlin), Postdoc, Chemical Biology (Cornell University, USA)

 

 

 

Associate Professor of Organic Chemistry

 

Chairperson of Chair of Oman’s Medicinal Plants and Marine Natural Products

 

Assistant Dean for Graduate Studies and Research

 

 

aharrasi@unizwa.edu.om

 

 

www.unizwa.edu.om/COMPMNP

 

 

 

 

Subject                                                                                                            Page

1. PERSONAL INFORMATION                                                                   4

2. EDUCATION                                                                                             4

3. TEACHING ACTIVITIES                                                                          5

3.1 Courses Coordinated and Taught                                                         5

3.2 Curriculum Development                                                                      7

3.3 Preparation of Laboratory Manuals and Lecture Notes             7

3.4 Final Year Projects Supervision                                                           7

3.5 Degree plans preparations and revisions                                               8

4. PROFESSIONAL EXPERIENCE                                                               9

4.1 Research Experience and Fund Raising                                      9         

4.1.1 Research Infrastructure Building                                                          9

4.1.2 Capacity Building & Researchers Development                                   9

4.1.3 Funded Projects                                                                                 10

4.1.3.1 Funded Research Projects                                                               10

4.1.3.2 Funded Industrial Projects                                                   11

4.1.3.3 Submitted Research Projects                                                           11

4.1.3.4 Research Projects in Preparation                                                     11

4.1.3.5 Funded FURAP Projects                                                                12

4.1.3.6 Strategic Projects in Preparation                                                      12

4.1.4 Purchased Capital Equipment                                                             12

4.2 Supervisory Experience                                                                         13

4.2.1 Postdoctoral Supervision                                                                    13

4.2.2 PhD Supervision                                                                                14

4.2.3 MSc Supervision & Examination                                                        14

4.3 Active International Collaborators                                                          14

4.4 Current Research Group Members                                                        15       

5. INTERNATIONAL RECOGNETION                                                        16

 5.1 Contribution to Journals                                                                        16

 5.2 International Awards                                                                             16

5.3 Invited Lectures & Research Invitations and Visits                                 16       

5.4 Research & Collaborators Visits                                                           17

6. ADMINISTRATIVE RESPONSIBILITIES AND COMMITTEES 18

6.1 Country Level                                                                         18

6.2 University Level                                                                                   18

6.3 College Level                                                                                      18

6.4 Department Level                                                                                18

6.5 Major Contributions to the University of Nizwa                                    19

7. MEMBERSHIPS AND COMMUNITY SERVICE                         19

8. PUBLICATIONS                                                                                        19

8.1 Book Chapters                                                                                    19

8.2 Research Papers                                                                                  19

8.3 Conference Proceedings and Invited Lectures                                      32

8.4 Posters and Abstracts                                                                          33

9. WORKSHOPS                                                                                           34

10. RESEARCH ACTIVITIES                                                                        34

10.1 My Research Vision                                                                          34

10.2 Areas of My Research Interests and Projects                                     36

10.2.1 Chemical Study of Boswellia sacra Resin Fumes                            36

10.2.2 Asymmetric Synthesis                                                                     39

10.2.3 Synthesis of isotopically-labeled thiamin pyrophosphate       39

10.3   Major Achievements                                                                        37

10.3.1 Chair of Oman’s Medicinal Plants and Marine Natural Products 39

10.3.1 National Chair in Materials Science and Metallurgy             40       

11. LANGUAGES                                                                                           41

12. REFERNCES                                                                                            41

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

DR. AHMED AL-HARRASI

 

 

 

 

1. PERSONAL INFORMATION

 

Name: Ahmed Sulaiman Al-Harrasi

Current Positions:

·        Chair -UoN Chair of Oman’ Medicinal Plants and Marine Natural products

·        Assistant Dean for Graduate Studies and Research

·        Associate Professor of Organic Chemistry

·        Visiting Professor- University of Southampton, UK

 

 

Date of Birth: 13-10-1974

Address: Sultanate of Oman, University of Nizwa, College of Arts & Science, Department of Biological Sciences and Chemistry, P.O Box 33, PC 616, Birkat Al-Mouz, Nizwa, Tel: (968)-92828487

 

E-mail: aharrasi@unizwa.edu.om

 

Homepage: www.unizwa.edu.om/COMPMNP

 

Nationality: Omani

 

2. EDUCATION

 

Certificate

Award

Duration

School/University

Postdoctoral in Chemical Biology

Fulbright

Award

 

2008-2009

Cornell University/USA

PhD in Synthetic Organic Chemistry

Summa Cum Laude

DAAD

Award

2002-2005

Freie Universität Berlin/ Germany

MSc in Synthetic Organic Chemistry

(course work + research)

SQU

Scholarship

2000-2002

 

Freie Universität Berlin/ Germany

 BSc Chemistry

 

1997-2000

Sultan Qaboos University/ Muscat/Oman

BEd  Chemistry/Physics

 

1993-1997

Sultan Qaboos University Muscat/Oman

 

 

3. TEACHING ACTIVITIES

 

3.1  Courses Coordinated and Taught

 

Course Code

Course Name

Semester

 

No. of times taught

Role

Students Intake

Nature of the course

University

CHEM422

Identification of Organic Compounds

Spring 2013, Fall 2012, Fall 2011, Fall 2010

4

Coordinator & Instructor

10-25

Theory

University of  Nizwa

CHEM325

Advanced Organic Chemistry Laboratory

Spring 2013, Spring 2012, Fall 2010, Fall 2009

4

Coordinator & Instructor

5-20

Advanced laboratory

University of  Nizwa

CHEM499

Chemistry Project

Spring 2013, Spring 2012, Fall 2010, Spring 2010

4

Coordinator & Instructor

5-10

Research Project

University of  Nizwa

CHEM275

Organic Chemistry II

Fall 2012, Fall 2011, Summer 2010, Spring 2010, Fall 2009, Spring 2008,

Fall 2007,

Spring 2007

8

Coordinator & Instructor

35-60

Theory & Laboratory

University of  Nizwa

CHEM280

Edible Oil Chemistry

Spring 2011, Spring 2010

 

 

 

 

2

Coordinator & Instructor

10

Theory

University of  Nizwa

CHEM265

 

 

Organic Chemistry I

Summer 2010, Fall 2009, Spring 2008, Fall 2007, Spring 2007

5

 

Coordinator & Instructor

60-120

 

 

 

 

 

Theory & Laboratory

University of  Nizwa

CHEM101

General Chemistry I

Summer 2006

1

Coordinator & Instructor

120 (two sections)

Theory and Laboratory

University of Nizwa

CHEM386

Petroleum Chemistry

Fall 2007

1

Coordinator & Instructor

 

Theory

University of  Nizwa

CHEM 3321

Introduction to organic chemistry

Fall 2006

1

Instructor

60

Theory and Laboratory

Sultan Qaboos University

CHEM 5000

Chemistry Project

Spring 2008, Fall 2007, Spring 2007, Fall 2006

4

Instructor

2

Research Project

Sultan Qaboos University

CHEM 2101

General chemistry I

Spring 2006

1

Instructor

60

Theory and Laboratory

Sultan Qaboos University

CHEM 2091

Introduction to organic chemistry

Spring 2003

1

Instructor

60

Theory and Laboratory

Sultan Qaboos University

CHEM011

General Chemistry for Foundation Program

Summer 2008, Winter 2009, Summer, 2010, winter 2010, Summer 2011

5

Coordinator & Instructor

30-50

Theory and Laboratory

German University of Technology in Oman

CHEM022

Chemistry for Geosciences

Winter 2009

1

Coordinator & Instructor

35

Theory and Laboratory

German University of Technology in Oman

 

 

3.2  Curriculum Development

 

  1. I designed a curriculum for CHEM 480 Edible Oil Chemistry.
  2. I designed a curriculum for CHEM 422 Identification of Organic Compounds from Spectra  
  3. I designed a curriculum for CHEM 265 Organic Chemistry I
  4. I designed a curriculum for CHEM 275 Organic Chemistry II
  5. I designed a curriculum for CHEM 422 Identification of Organic Compounds
  6. I designed a curriculum for CHEM 386 Petroleum Chemistry 2007
  7. I designed a curriculum for CHEM 380 Industrial Chemistry 2007
  8. I designed a curriculum for CHEM 101 General Chemistry I
  9. I designed a curriculum for CHEM 011 General Chemistry for Foundation Program-Oman German University of Technology 2008.

 

3.3 Preparation of Laboratory Manuals and Lecture Notes

  1. Prepared the laboratory manual for CHEM 265 Organic Chemistry I
  2. Prepared the laboratory manual for CHEM 275 Organic Chemistry II
  3. Prepared the laboratory manual for CHEM 325 Advanced Organic Laboratory
  4. Prepared the laboratory manual for CHEM 101 General Chemistry I
  5. Prepared the laboratory manual for CHEM 011 General Chemistry for foundation studies.

 

3.4 Final Year Projects Supervision

1.      Aisha Al-Balushi, anti-bacterial and anti-fungal activities of 32 varieties of dates palm trees grown in Oman, 2013. 

2.      Laila Al-Shaibani, Isolation and Structure Elucidation of AKBA, 2013.

3.      Marwa Al-Alawi, Isolation and Structure Elucidation of ABA, 2013.

4.      Khalid Al-Riyami, Physiochemical Investigations of Omani Frankincense, 2011.

5.      Fatma Al-Maqbali, Isolation of boswellic acid derivatives from Omani frankincense, 2011.

6.      Zainab Al-Qasmi, Isolation of boswellic acid derivatives from Omani frankincense, 2011.

7.      Salma Al-Matani, Microwave distillation of boswellia sacra resins, 2011. 

8.      Maryam Al-Badi, Nutritive analysis of frankincense resin, 2011.

9.      Ahlam Al-Hadid, Synthesis of New coumarin Deruivatives from anthracene, Fall 2010.

10.  Iman Al-Hosni, Synthesis of Coumarin 4 Derivatives, Fall 2010.

11.  Mubarak Al-Ghafri, Mariyam Al-Senaidi, Chemical Composition of Five Varieties of Omani Date Kernels.

12.  Asma Al-Battashi, Amna Al-Muqiani, Phytochemical Analysis of Boswellia sacra, 2008-2009.

13.  Azza Al-Kalbani, Synthesis of New Coumarin Derivatives, 2007-2008, SQU.      

14.  Zainab Al-Hinai, Synthesis and Luminescence Properties of a Novel Label Based on Coumarin Nucleus, 2006-2007 (co-supervisor), SQU.

15.  Jan Jebers, Stereoselective Synthetic Approach to a 1,2-Diaminosugar Derivatives, 2005, Freie Universität Berlin.

16.  Torsten Schwich, Lewis Acid Promoted Intramolecular Cyclisation of 1,2-Oxazines: Synthesis of Highly Functionalised Enantiopure Pyran Derivatives, 2004, Freie Universität Berlin.

17.  Moritz Kühnel, Intramolecular Rearrangement of 3,6-Dihydro-2H-1,2-Oxazine, 2004, Freie Universität Berlin.

18.  Markus Gerhard, Synthesis of 1,2-Oxazine Derivatives from D-Glyceraldehyde Derived Nitrone and 2-Trimethylsilylethoxyallene, 2004, Freie Universität Berlin.

19.  Simon Grabowsky, Synthesis of 1,2-Oxazine Derivatives from D-Glyceraldehyde Derived Nitrone and 2-Trimethylsilylethoxyallene, 2004, Freie Universität Berlin.

20.  Nadine Tetzlaff, Synthesis and Reactions of BDA-Protected-Glyceraldehyde derived N-Benzyl Nitrone, 2004, Freie Universität Berlin.

21.  Eda Yegen, Synthesis of syn-1,2-Oxazine Derivative, 2003, Freie Universität Berlin.

22.  Michal Wieko, Synthesis and Reactions of New Derivatives of 1,2-Oxazines, 2003, Freie Universität Berlin.

 

3.4 Degree plans preparations and revisions

 

I have contributed significantly in the revision BSc Chemistry degree plan in 2006 and 2012 by chairing the degree plan departmental committee .

4. PROFESSIONAL EXPERIENCE

 

4.1 Research Experience and Fund Raising                          

 

4.1.1 Research Infrastructure Building

1. I have established two Synthetic and Natural Products laboratories with state-of-the-art facilities at DARIS centre for Research at the University of Nizwa with capital equipment exceeds 900,000 OR (2,337,358 USD).

2. I have established a microbiology laboratory with state-of-the-art facilities at DARIS centre for Research at the University of Nizwa with capital equipment exceeds 250,000 OR (390,000.2 USD).

3. I have leaded the negotiation for Science Direct which was successfully launched in the University of Nizwa in April 2011 with a budget of 50,000 OR (131,000 USD).

4. We have purchased 600 MHz NMR from Bruker through TRC funds which will be launched in December 2013 with a budget of 481,311 OR (1,250,000 USD). This is the first NMR system in the middle east with CryoProbe™ Prodigy, the Successful  Affordable Game-Changer for Routine NMR that delivers 3-fold Sensitivity Boost and 10-fold Throughput Enhancement.

 

5. Prepared with the chancellor the proposal for the creation of a research chair in materials science and metallurgy at the University of Nizwa in collaboration with the University of Cambridge which was funded with a budget of 5,126,940 OR (13,319,320.80 USD).

 

6. Initiator of the following supportive projects: Animal House Facility, Glassblowing Workshop, Liquid Nitrogen Plant.

 

 

4.1.2 Capacity Building & Researchers Development

 

1. Our laboratories hosted 8 exchange PhD and MSc students from Oman and other countries. More than 30 BSc students have performed their final year projects under my supervision.

 

2. I have also trained more than 100 graduates from all higher education institutes in the Sultanate.

 

 

 

 

 

4.1.3   Funded Projects

 

4.1.3.1  Funded Research Projects

 

Total budget: 4,575,620 OMR (11,892,449.38 USD)

 

1. Ahmed Al-Harrasi, Chair of Oman’s Medicinal Plants and Marine Natural Products, approved and announced (budget of 3,748,000 OMR, 9,748,992.36 USD).

 

2. Javid Hussain, Ahmed Al-Harrasi, Simon Gibbons, Gilles J. Guillemin, Phytochemical Investigations, Proximate Analysis and Biological Investigation of Some Selected Omani Medicinal  Plants. ORG/CBS/12/004, approved (budget 528, 00 OR, 1,495,582.17 USD).

 

3. Ahmed Al-Harrasi, Ahmed Al-Rawahi, Jamal Al-Sabahi, Javid Hussain, Comparative, Physicochemical and Microbiological Investigations of Omani Luban (Boswellia sacra) and Related Frankincense Species, 2011-2014. (ORG/CBS/10/002) (approved budget 177,540 OR, 460,879.51 USD) 

 

4. Ahmed Al-Harrasi, Ahmed Al-Rawahi, Comparative and Phytochemical Study of Omani Luban (Boswellia sacra) and Related Frankincense Species, 2010. (A/09-10-UoN/28/A&S/IF) (approved budget 14,000 OR, 36358 USD).

 

5. Javid Hussain, Ahmed Al-Harrasi, Phytochemical Investigations, Proximate Analysis and Biological Investigation of Some Selected Omani Medicinal  Plants " No  A/URC/2011-12/CA and S/03/November, 2011.  (approved budget 19,700 OR, 51,036 USD).

 

6. Yahya Ismail, Ahmed Al-Harrasi, Fabrication of Conducting Polymer based Artificial Muscles and Evaluation of their Actuation and Sensing Characteristics, 2010-2012. P-09-10/UoN/29/CA&S/IF (approved budget 8500 OR, 22,074.77 USD).

 

7. Ann Mothershaw, Ahmed Al-Harrasi, Basil Nzeako, Physicochemical Properties and Antimicrobial Activity of Omani Frankincense, 2010-2012. (approved budget 4500 OR, 11,686.64 USD).

 

8. Salma Al-Kindy, Ahmed Al-Harrasi, Synthesis and Luminescence Properties of a Novel Label Based on Coumarin Nucleus, 2007-2010. (approved budget 4500 OR, 11,686.64 USD).

 

9. Issa Al-Amri, Ibraheem Mahmood, Abdulaziz Al-Kindy, Ahmed Al-Harrasi, The Effect of incubation temperature on sex determination in relation to reproductive steroid levels, progesterone receptors and gonadal ultra-structural steroid genic features in embryos and post hatchings of the green turtle, Chelona mydas, Oman approved budget 15,300 OR, 39,802USD).

 

4.1.3.2   Funded Industrial Projects-Ministry of Industry& Commerce

 

1. P-2012-001 Frankincense Characterization to determine purity and health benefits and confirm Omani origin. The development of a new fragrance using endemic flowers and fruits of Oman. (approved budget 31,880 OR (82590 USD).

 

4.1.3.3   Submitted Research Projects

 

1. Exploration of Selected Seaweeds from Marine Resources of Sultanate of Oman as a Source of Potential Lead Compounds for the Development of New Drugs. To TRC

 

b. Discovery of Effective Anticancer Agents from Omani Medicinal Plants. TO TRC

 

2. Exploration of extremophilic endophytes as an alternative to remediation of heavy metals contamination in Oman. TO TRC

 

3. Investigation of Nanostructure of Stratum corneum lipid model membranes by using X-ray- and neutronscattering Techniques. TO TRC

 

4. Exploration of Selected Algal Bloom Causing Species from Marine Resources of Sultanate of Oman as a Source of Potential Lead Compounds for the Development of New Drugs. To Ministry of Agriculture and Fisheries Wealth

 

4.1.3.4   Research Projects in Preparation

 

1.  Enhancement of the Most Active Anti-Cancer Boswellic Acid (AKBA) in Boswellia Sacra Extract.

 

2.  Discovery of New Antagonists of Glucagon Receptor and Protein Glycation, α-Glucosidase, Dipeptidyl Peptidase-4 Enzymes Inhibitors from Natural and Synthetic Products for the Management of Diabetes Mellitus and Late Diabetic Complications.

 

3.  FT-IR Based Quantification of Glucose, Fructose and Sucrose in Date Palm Varieties grown in the Sultanate of Oman.

 

4. AKBA Production Unit.

 

5. Double-Enhancement of the Most Active Anti-Cancer Boswellic Acid (AKBA) in Boswellia Sacra resin, Its Synthetic Modifications and Anti-Cancer Activities.

 

6. Is frankincense a plant product or a fungi-product?

4.1.3.5   Funded FURAP Projects

 

1. Condensation and Analysis of the Frankincense Resin Incense. Budget  2400 OMR.

 

4.1.3.6   Strategic Projects in Preparation

 

1.      Eco-friendly and Physiological strategies to control Ommatissuslybicus de Bergevin (Dubas Bug) on Date Palm (Phoenix dactylifera) leaves in Oman.

 

4.1.4   Purchased Capital Equipment

 

Through my externally and internally funded projects, I have purchased massive capital equipment that are fully functioning which serve the whole university. The major ones include:

 

1.      Bruker AVANCE-III 600MHz High Resolution FT- NMR spectrometer

with ASCENDTM Ultra Long Hold Time Magnet and Prodigy CryoProbe & CryoPlatform with a budget of  1,188,068 USD.

 

2.      Bruker Amazon Sl Basic System with High Performance Esi Lc/Msn Ion Trap Ms System With Dual Funnel Ion Guide with a budget of 289,220.00 USD.

 

3.      Bruker FT-IR spectrometer TENSOR 37 with a budget of  48.82562 USD.

 

4.      JAI Recycling Preparative HPLC Automated system with a budget of 72,807.99 USD.

 

5.      JAI Recycling Preparative HPLC Manual system with a budget of  57,517.96 USD.

6.      AAnalyst Perkin Elmer 400 Atomic Absorption Spectroscopy.

 

7.      Bruker ICP-MS aurora M90.

 

8.      Waters Quattro Premier XE( LC/MS/MS)

9.      Gas Chromatography- Flame Ionization Detector(GC-FID), Varian 3900

10.  High performance liquid chromatography –water 2690 separation module with  UV-VIS 2487 Dual λ Absorbance Detector

11.  UV-VIS 2487 Dual λ Absorbance Detector.  

 

12.  P3000 Automatic Polarimeter with a budget of 6,548.95 USD.

 

13.  NEOS Microwave System for Rapid Extraction of Essential Oils with a budget of 18,441.56 USD.

 

14.  Buchi K-360 and K-439 KjeldahL Distillation and Digestion units with a budget of 48,598.65 USD.

 

15.  Yamato Rotary Evaporators with a budget of 52,022.37 USD.

 

16.  Other instruments include Inverted microscope, orbital shaker, laminar flow, autoclave, PCR, Refractometrs, Centrifuges, Ultrasonic Baths, Fraction  Collectors, Melting Point Meters, Moisture  analyzers, Vortex mixers, Water Distillers,  Electric Grinders, Incubators, Furnaces, Analytical Balances, Eliza, autoclaves, Shakers with a budget of 400,011.19 USD.

 

4.2  Supervisory Experience

 

4.2.1 Postdoctoral Supervision

 

1. Dr. Najeeb Rehman, Isolation of biologically active compounds from the Boswellia sacra resin, 2010-todate. 

 

2. Dr. Liaqat Ali, Isolation of biologically active compounds from the Boswellia sacra resin, 2010-todate. 

 

3. Dr. Hidayat Hussain, Isolation of biologically active compounds from the Boswellia sacra resin, 2011-date. 

 

4. Dr. Luqmanul Hakeem, In vitro and In vivo anti-cancer activities of Omani Medicinal Plants, 2012-date.

 

5. Dr. Abdul Latif Khan, Allelochemistry and secondary metabolites, 2011-date. 

 

 

4.2.2 PhD Supervision

 

1. Somya shanmuganathan, From chemoprevention to identification of potential therapeutic target(s) and biomarkers for breast cancer, 2012. Co-supervision

 

2. Samina Ali, Bio-guided Isolation of Phytochemicals from Omani Medicinal Plants, 2011, Joint supervision with Qauid Azem University, Pakistan. Co-supervision

 

3. Nisar Ahmed, Bio-guided Isolation of Phytochemicals from Omani Medicinal Plants, 2011, Joint supervision with Qauid Azem University, Pakistan. Co-supervision

 

4.2.3 MSc Supervision & Examinations

 

1. Zahra Al-Kharusi, Physicochemical properties and antimicrobial activity of Omani frankincense, 2009-2010. (co-supervisor)

2. Sulaiman Al-Sulaimi, Synthesis and Luminescence Properties of a Novel Label Based on Coumarin Nucleus, 2010-2011. (co-supervisor)

3. Zaid Al-Alawai, 2012, Department of Chemistry, SQU (external examiner)

4. Thuraya Al-Harthy, 2013, Department of Chemistry, SQU (external examiner)

 

4.3  Active International Collaborators

 

 

Name of Collaborator

Country Flag

Institution

Research Area

1

Prof. Simon Gibbons

http://www.flags.net/images/smallflags/UNKG0001.GIF

Schools of Pharmacy, University of London, UK

Phytochemistry & Medicinal Plants

2

Prof. James Paulson

http://www.flags.net/images/smallflags/UNST0001.GIF

University of Wisconsin Oshkosh, USA

Cell division and apoptosis

3

Prof. Alan Katritzky

http://www.flags.net/images/smallflags/UNST0001.GIF

University of Florida, USA

Synthesis of Natural Products

4

Prof. Tadhg Begley

http://www.flags.net/images/smallflags/UNST0001.GIF

University of Texas A&M, USA

Chemical Biology

5

Prof. Gills Gullimen

http://www.flags.net/images/smallflags/ASTL0001.GIF

University of New South Wales, Australia

Cancer Research

6

Prof. Hans Resissig

http://www.flags.net/images/smallflags/GERM0001.GIF

Free University of Berlin, Germany

Synthesis of Natural Products

7

Dr. John Langley

http://www.flags.net/images/smallflags/UNKG0001.GIF

University of Southampton, UK

Mass Spectroscopy

8

Dr. Eike Reich

http://www.flags.net/images/smallflags/SWIT0001.GIF

CAMAG Laboratory, Switzerland

HPTLC

9

Dr. Doha Al-Waheeb

http://www.flags.net/images/smallflags/KUWA0001.GIF

Kuwait University, Kuwait

Natural Products

10

Dr. Mansoor Ahmad

http://www.flags.net/images/smallflags/PAKS0001.GIF

Kohat University of Science & Technology, Pakistan

Microbiology

11

Dr. Ishfaq Bukhari

http://www.flags.net/images/smallflags/SAAR0001.GIF

King Saud University, KSA

Heart attack and hypotension activities

12

Dr. Allal Ouhatit

http://www.flags.net/images/smallflags/OMAN0001.GIF

Department of Genetics, College of Medicine, SQU, Oman

Molecular Biology and Cancer Research

13

Ms. Fatema Al-Khulaifi

http://www.flags.net/images/smallflags/QATA0001.GIF

Qatar Foundation

 

Botany

14

Prof. James Tukson

http://www.flags.net/images/smallflags/UNST0001.GIF

University of Hawaii Cancer Center

Cancer Research

15

Prof. Taehee Han

Sungkyunkwan University School of Medicine, Republic of Korea

Cancer Research

 

4.4  Current Research Group Members under the Chair

 

 

Name

Duration

Position

Research Topic

1

Dr. Ahmed Al-Harrasi

 

Chair Professor

All Research Topics

2

Dr. Javid Hussain

from 2010 to date

Deputy Chair

All Research Topics

3

Dr. Obaid Khan

From 2013 to date

Technical Director

Procurement and Instrumentation

4

Dr. Liaqat Ali

from 2010 to date

Researcher

Phytochemistry and Polypeptide Synthesis

5

Dr. Hidayat Hussain

from 2011 to date

Researcher

Synthetic- and Phytochemistry

6

Dr. Najeeb Rehman

from 2010 to date

Researcher

Phytochemistry and Proximate analysis

7

Dr. Luqman Hakkim

from 2011 to date

Researcher

Cancer Research

8

Dr. Abdul Latif Khan

from 2012 to date

Researcher

Allelochemistry and secondary metabolites

 

9

Dr. Abbas Ahmed

from 2012 to date

Researcher

Antiglycation Agents from Natural Products

10

Dr. Qazi Mohammed

from 2012 to date

Researcher

Microbiology/

Virology

11

Dr. Zakira Naureen

from 2012 to date

Researcher

molecular microbiology

12

Dr. Syed Gilani

from 2012 to date

Researcher

Plant Taxonomy

13

Dr. Muzafar Ahmed

from 2014 to date

Researcher

Cancer Research

14

Dr. Hussain Yar

from 2014 to date

Researcher

Cancer Research

15

Dr. Zahid Hussain

from 2014 to date

Researcher

Synthesis

16

Mr. Sulaiman Al-Sulaimi

from 2012 to date

Associate

Researcher

Synthesis

17

Mr. Mohammed Al-Brumi

from 2011 to date

Assistant

Researcher

Phytochemistry

18

Mr. Rashid Al-Harrasi

from 2010 to date

Technician

Instruments and lab work

19

Ms. Amna Al-Riyami

from 2013 to date

Assistant

Researcher

Phytochemistry

20

Mr. Aflah Al-Hadrami

from 2011 to date

Administrative

Director

Administrative

Work

21

Mr. Mohammed Najjar

from 2013 to date

Assistant

Researcher

Biotechnology

22

Amjad Khan

from Jan 2013

Exchange PhD Student

Isolation of bioactive compounds

23

Riaz Ahmed

from Jan 2013

Exchange PhD Student

Isolation of bioactive compounds

24

Imtiaz Hussain

from Jan 2013

Exchange PhD Student

Isolation of bioactive compounds

25

Hidayat Ullah

from Jan 2013

Exchange PhD Student

Isolation of bioactive compounds

 

4.5  Former Group Members

 

1

Prof. Tee Han (South Korea)

from Jan 2013-June 2013

Visiting Professor

Cancer research

2

Samina Ali

from Jan 2013

Exchange PhD Student

Phytochemistry

3

Nisar Ahmed

from Jan 2013

Exchange PhD Student

Phytochemistry

 

5. INTERNATIONAL RECOGNETION

 

Conference Chair: LabTech 2014 to be held in Manama, Bahrain from 28th-30th October 2013.

 

Conference Chair: 1st International Conference of Medicinal Plants in Oman, Oman, University of Nizwa,  November,  2013.

 

5.1  Contribution to Journals

 

1.      National Representative for the Gulf States for Journal  ARKIVOK (Achieve for Organic Chemistry), Florida, USA).

2.      Reviewer for several organic and medicinal chemistry journals.  

 

5.2  International Awards

                                                                           

  1. DAAD Award by the German Academic Exchange Service, 2003-2006.
  2. Fulbright Award by the Council for International Exchange of Scholars (CIES), USA, 2008-2009.

 

5.3  Invited Lectures & Research Invitations and Visits

 

  1. Official visit, Invitation by vice-chancellor of University of Agriculture Faisalabad, Faisalabad, September 2012, MOU will be signed.
  2. Official visit, Invitation by vice-chancellor of COMSATS University, Islamabad, September 2012, MOU will be signed.
  3. Official visit, Invitation by chairperson of Pakistan Council for Science and Technology, Islamabad, September 2012, MOU will be signed for the establishment of Technology Incubation Centers at the University of Nizwa.
  4. Official visit, Invitation by vice-chancellor of Quaid-I-Azem University, Islamabad, September 2012, MOU will be signed.
  5. Invited Speaker and chair of session in First Pharmacy conference, 2012, University of Nizwa, Oman, 24-26 January 2012.
  6. Research visit, ETH Zurich, Zurich, Switzerland, November 2011.
  7. Invited Speaker and chair of session in LabTech 2011, Doha, Qatar, 09-12 October 2011.
  8. Research visit, Department of Chemistry, University of Southampton, UK, July 2011.
  9. Research visit, School of Pharmacy, University of London, UK, July 2011.
  10. Invited Lecture, Department of Health Sciences, Qatar University , Doha 24th May 2011.
  11. Invited Speaker at the 3rd International Conference on Drug Discovery & Therapy, Dubai UAE, 7th-10th February 2010.
  12. Invited Speaker at the 11th Florida Heterocyclic Conference, Florida, USA, 6th -10th March 2010.
  13. Invitation for Research Visit at University of Manchester, UK, May 2009
  14. Invitation for Visiting Scientist at Cornell University, USA, October 2008-March 2009
  15. Invited Speaker as Fulbright OLP at University of Wisconsin, USA, 5th – 7th February 2009.
  16. Invited Speaker at Cornell University (Department of Chemistry and chemical Biology), USA, December 2009
  17. Invited Speaker at the 10th Florida Heterocyclic Conference, Florida, USA, 8th -11th March 2009.   
  18. Invited Speaker at the Summer School, Technical University of Braunschweig, 23-29 March 2009, Germany.
  19. Invited Speaker at UNESCO World Conference on Education for Sustainable Development, Bonn, 1st-4th April 2009, Germany.
  20. Invitation for Research Visit at Cornell University, USA, October 2008
  21. Invited Speaker and Chairperson of session XI at the 5th European – Asian (Euroasian) Meeting on Heterocyclic Chemistry (EAMHC 5) in Kuwait 2008.  
  22. Keynote Speaker, Member of the scientific committee and chairperson of the second session in International Conference on Complementary System of Medicine, Singapore 2007.
  23. Invited Speaker at Arab Naturals 2007 -Traditional and Complementary Healthcare Expo & Conferences, Abu Dhabi, UAE, 2007.
  24. Invitation for Research Visit from Freie Universitat Berlin, Germany 2007.
  25. Invitation for Research Collaboration from Analyticon Discovery, Germany 2007.
  26. Invited Speaker at the COMSTECH-TWAS Young Scientists Conference at the Interface of Chemistry and Biology, Islamabad, Pakistan, 2006.
  27. Invited Speaker at the Biannual Conference in Chemistry, Egypt, 2006.

 

5.4  Research & Collaboration Visits

 

Kuwait, Qatar, United Arab Emirates, Saudi Arabia, Bahrain, Jordan, Egypt, United States of America, United Kingdom, Switzerland, Germany, France, India, Pakistan, Singapore, Malaysia.

 

 

6. ADMINISTRATIVE RESPONSIBILITIES AND COMMITTEES

 

6.1  Country Level

 

1.      Member of the Oman Research and Education Network (OMREN)

 

6.2  University Level

 

  1. Chairperson- Oman’s Medicinal Plants and Marine Natural products 2012 to date.
  2. Vice-chairperson of the Steering Committee of   DARIS Research Canter.
  3. Member of the University Academic Council, 2010 to date.
  4. Member of the University Research Council 2011 to date.
  5. Member of the University Chairs Committee
  6. Member of the University Research Projects Committee
  7. Member of the University Graduate Studies Committee
  8. Member of the Academic Recruitment Committee
  9. Member of the University Publication Board

10.  Member of the University Faculty Mentored Undergraduate Research Award Program (FURAP).

 

6.3  College Level

 

  1. Acting Dean during the absence of the Dean CAS.
  2. Assistant Dean for Graduate Studies and Research, College of Arts and Sciences, 2011-to date.
  3. Assistant Dean for Training, College of Arts and Sciences, 2010-2011.
  4. Member and Convenor of the College Promotion Committee.
  5. Member of the college board.
  6. Member of the college executive committee.

 

6.4  Department Level

 

  1. Acting Head of Department of Biological Sciences and Chemistry during the absence of the HOD, several times.
  2. Head of degree Plan Committee 2009-date.
  3. Head of Training & Field Trips Committee 2010-2011.
  4. Member of the Department Promotion Committee.
  5. Member of the Department Reports Committee.
  6. Chemistry Department Representative to the College Board 2009-2010.
  7. Member of the Time Table Committee.
  8. Member of the Review and upgrading department committee.

 

 

6.5  Major Contributions to the University of Nizwa

 

1.      Establishment of a Research Group in Natural Products Chemistry with 15 scientists.

2.      Preparation of the Chair of Medicinal Plants and Marine Natural Products with a budget of 3,748,000 OMR

3.      Strongly involved in preparation of Cambridge Chair of material sciences & Metallurgy approved with a budget of 5,126,940 OMR from TRC.

4.      Revision and Amendment of UoN Research Strategy

5.      Preparation of the MSC program in Chemistry

6.      Contributed to the College of Arts and Sciences Strategic Plan

7.      Contributed to the Department of Biological Sciences Strategic Plan

8.      Contributed to the BSc in chemistry degree program

 

 

 

7. MEMBERSHIPS AND COMMUNITY SERVICE

 

1.      Member of the Phytochemistry Society of Europe

2.      Member of the American Chemical Society

3.      Chairman of the Omani Chemical Society, Project pending for approval.

4.      External examiner for MSc students in Sultan Qaboos University.

5.      External examiner for the institutes of Health Sciences, Ministry of Health since 2010.

6.      External examiner, School of Pharmacy, University of Nizwa.

7.      Delivery of lectures at high schools of the ministry of education.

 

 

 

8. PUBLICATIONS

 

8.1  Book Chapters

 

1. Ahmed Al-Harrasi, Hidayat Hussain, Essential Oils in Food Production, Preservation, Flavour and Safety, Frankincense (Boswellia ) oils, Elsevier 2013.

 

2. F G Cordova, Y A Ismail, J G Martinez, Ahmed Al Harrasi, T F Otero, Conducting polymers are simultaneous sensing actuators, 01/2013; DOI:868708 10.1117/12.2009609 In book: Electroactive Polymer Actuators, 2013.

 

8.2  Research Papers

 

Year 2013

 

Accepted

 

1.        Hussain H.; Al-Harrasi A.; Hussain J.; Al-Rawahi A.; Gibbons S.; From 2002 to 2012: A Fruitful Decade for Antileishmanial Compounds, Chemical Reviews, 2013, proposal accepted. (Impact factor 41.56)

 

2.        Al-Harrasi A.; Hussain H.; Hussain J.; Al-Rawahi A.; Structure, Bio-activity and Chemical Synthesis of Boswellic Acids and Other Terpenoids in Genus Boswellia, Chemical Reviews, 2013, accepted. (Impact factor 41.56)

 

3.        Hussain J, Rehman N, Hussain H, Ali L, Al-Harrasi A, Ahmad VA,  Nepethalates A and B: Two New Phthalate Derivatives from Nepeta clarkei, Helvitica Chemica Acta 2011, In press. (Impact factor 1. 478)

 

4.        Rehman N.; Hussain J.; Ali L.; Hussain J.; Khan AL.; Gillani SA.; Al-Harrasi A.; Nutritional Assessment and Mineral Composition of Some Selected Edible Vegetables, European Journal of Medicinal Plants, 2013, accepted, Galley proof received.

 

5.        Ali S.; Hussain J.; Al-Harrasi A.; Rizivi TS.; Shah ST.; Ali L.; Floccosic Acid-A New Triterpenic Acid from Nepeta floccose, Helvetica Chimica Acta, in press. (Impact factor 1. 478)

 

6.        Preliminary comparative analysis of four botanicals used in the traditional medicines of pakistan, JavidHussain, Najeeb Ur Rehman, Abdul Latif Khan, Zabta Khan Shinwari, Ahmed Al-Harrasi, Liaqat Ali, and FazalMabood, accepted, Pakistan Journal of Botany, accepted. (Impact factor 1.0)

 

Published

 

7.        Al-Harrasi A.; Rehman N.; Ali L.; Hussain J.; Hussain H.; Al-Rawahi A. EBA and Nizwanone: One New Boswellic Acid Derivative and New Triterpene from Boswellia sacra, Chemistry & Biodiversity, 2013,  10, 1501-1506. (Impact factor 1.94)

 

8.        Hussain, H.; Al-Harrasi, A.; Ahmed, I.; Green, I. R; Van Ree, T.; Ghulam. A. Chemistry and biology of the genus Pluchea. Chem. Biodiver, 2013, 10, 1944-1971. (Impact factor 1.90)

 

9.        Khan AL.; Hussain J.; Al-Harrasi A.; Al-Rawahi A.; Lee IJ.; Endophytic fungi: resource for Gibberellins and crop abiotic stress resistance, Critical Reviews in Biotechnology, 2013, published online(Impact factor 5.41)

 

10.    Al-Harrasi A.; Hussain H.; Al-Rawahi A.; Hussain J.; Chemistry and Biology of Essential Oil of Genus Boswellia, Evidence-Based Complementary and Alternative Medicine, 2013, 140509.  (Impact factor 1.77)

 

11.    Al-Harrasi A.; Hussain H.; Al-Rawahi A.; Hussain A. Chemistry and Biology of Essential Oil of Genus Boswellia, Evidence-Based Complementary and Alternative Medicine, 2013, 140509. (Impact factor 1.77)

 

12.    Khan AL.;, Waqas M.; Hamayun M.; Al-Harrasi A.; Al-Rawahi .; Lee IJ. Co-synergism of endophyte Penicillium resedanum LK6 with salicylic acid helped Capsicum annuum in biomass recovery and osmotic stress mitigation, BMC Microbiology, 2013, 13:51. (Impact factor 3.1)

 

13.    Al-Kindy, S.; Al-Harrasi, A.; Al-Lawati H., High Performance Liquid Chromatography Determination of Anilines with Fluorescent Detection and Pre-column Derivatization, Instrumentation Science & Technology, 2013, 41, 48-59. (Impact factor 0.54)

 

14.    Al-Harrasi, A.; Al-Rawahi, A.; Hussain, J.; Ali, L.; Hussain, H.; Rehman, N.; Ghulam A.; Ahmad, M.; Mehjabeen, First in vitro Lipid peroxidation and in vivo Anti-inflamatory activity of the Omani Frankincense obtained from Boswellia sacra, International J. Phytomedicine, 2013, 5, 73-77. (Impact factor 0.89)

 

15.    Al-Harrasi, A.; Al-Rawahi, A.; Hussain, J.; Ali, L.; Hussain, H.; Rehman, N.; Ghulam A.; Ahmad, M.; Mehjabeen. Antiglycation and antioxidant activities and HPTLC analysis (identification of boswellic acid derivatives) of Boswellia sacra resin: THE SACRED FRANKINCENSE Tropical J. Pharm. Research, 2013, 12, 597-602. (Impact factor 0.84)

 

 

16.    Khan AL.; Hussain J.; Al-Harrasi A.; Lee IJ.; Fungal endophyte Penicillium janthinellum LK5 improves growth of ABA-deficient tomato under salinity, World Journal of Microbiology and Biotechnology, 2013, published online. (Impact factor 1. 46)

 

17.    Khan AL.; Waqas M.; Hussain J.; Al-Harrasi A.; Lee IJ.; Fungal endophyte Penicillium janthinellum LK5 can reduce Cadmium toxicity in Solanum lycopersicum (Sitiens and Rhe), Biology and Fertility of Soils, 2013, published online. (Impact factor 2.64)

 

18.    Hussain J.; Rehman N.; Khan AL.; Ali L.; Al-Harrasi A.; Shinwari ZK.; Hussain H.; Rizvi TS.; Proximate Based Comparative Assessment of Five Medicinal Plants to Meet the Challenges of Malnutrition, European Journal of Medicinal Plants, 2013, 3(3): 444-453.

 

19.    Al-Harrasi A.; Ali L.; Rehman N.; Hussain H.; Hussain J.; Al-Rawahi A.; Langley GJ.; Wells NJ.; Abbas G.;  Nine Triterpenes from Boswellia sacra and Their Chemotaxonomic Importance, Biochemical Systematics and Ecology, 2013, 51: 113-116. (Impact factor 1.35)

 

20.    Hussain J.; Rehman N.; Al-Harrasi A.; Ali L.; Khan AL.; Albroumi MA.; Essential oil composition and nutrient analysis of selected medicinal plants in Sultanate of Oman, Asian Pacific Journal of Tropical Disease, 2013, published online, doi:10.1016/S2222-1808(13)60095-X. (Impact factor 0.34)

 

21.    Balamurugan M.; Weli MA.; Edwards G.; Al-Harrasi A.; Al-Kharusi Z.; In Vitro Permeation Studies of Commercially available Diclofenac Sodium Gel (Sample Analysis Using LC-MS/MS) Through the Two Different Shed Snake Skins Obtained from Various Regions of Sultanate of Oman: a Pilot Study, Lat. Am. J. Pharm. 2013, 32 (7): 1069-73 (Impact factor 0.288)

 

22.    Hussain, J.; Rehman, N.; Hussain, H.; Ali, L.; Khan, N.; Al-Harrasi, A. (2013) Quality Characteristics of The Commonly Used Vegetables In Usterzai - A Native Village Of The Kohat Region, Pakistan Journal of Botany, 2013, 45, 2071-2074. (Impact factor 1.0)

 

 

Year 2012

 

23.    Hussain, H.; Hussain, J.; Al-Harassi, A. (2012) Chemistry and Biology of Genus Voacanga. Pharmacetical Biology, 50, 1183-1193. (Impact factor 1.23)

 

24.    Hussain H, Hussain J, Ali S, Al-Harrasi A, Saleem M, Abbas G, Riaz M, Anwar S, Hussain S, “Cichorins B and C: Two new benzo-isochromenes from Cichorium intybus” J. Asian Nat. Prod. Res., 2012, 14, 297-300. (Impact factor 0.948)

 

25.    Al-Kindy S, Al-Sharji N, Al-Harasi A, Suliman F, Al-lawati H, Schulman S, Synthesis and Spectroscopic Study of 2, 7-Diethylamino-2-oxo-2 H-chromen-3-yl benzothiazole-6-sulfonyl chlorides and its Derivatives, Arabian Journal of Chemistry, 2012, http://dx.doi.org/10.1016/j.arabjc.2012.06.015. (Impact factor 2.26)

 

26.    Nganga M, Hussain H, Chhabra S, Langat-Thoruwa C, Hussain J, Al-Harrasi A, Krohn K, Green IR, Eucleanal A and B: Two new Napthalene Derivatives from Euclea divinorum. Chinese Chemical Letters, 2012, 23, 576-578. (Impact factor 1.12)

 

27.    Hussain,J.; Naeema, Hussain, H.; Khan, F.U.; Rehman, N.U.; Al-Harrasi, A. Ajuganane: A New Phenolic Compound from Ajuga bracteosa. Nat. Prod. Comm. 2012, 7, 615-616. (Impact factor 1.242)

 

28.    Hussain, H.; Hussain, J.; Al-Harassi, A. (2012) Chemistry and Biology of Genus Voacanga. Pharmacetical Biology, 50, 1183-1193. (Impact factor 1.23)

 

29.    Hussain J, Rehman N, Hussain H, Al-Harrasi A, Ali L, Rizvi TS, Ahmad M, Mehjabeen, “Analgesic, anti-inflammatory, and CNS depressant activities of new constituents of Nepeta clarkei” Fitoterapia, 2012 83, 593-598. (Impact factor 2.233)

 

30.    Nganga MM, Hussain H, Chhabra S, Langat-Thoruwa C, Irungu BN, Al-Harrasi A, Riaz M, Krohn K, Antiplasmodial Activity Of Compounds From Drypetes gerrardii, Chemistry of Natural Compounds, 2012, 48, 304-305. (Impact factor 0.599)

 

31.    Ng’ang’a, M. M.; Hussain, H.; Chhabra, S.; Langat-Thoruwa, C.; Hussain, J.; Al-Harrasi, A.; Krohn, K. Eucleanal A and B: Two new naphthalene derivatives from Euclea divinorum. Chin. Chem lett., 2012, 23,  576–578. (Impact factor 1.21)

 

Year 2011

 

32.    Dekaris V, Pulz R, Al-Harrasi A, Lentz D, Reissig H, Stereoselective Syntheses of Aza, Amino and Imino Sugar Derivatives by Hydroboration of 3,6-Dihydro-2H-1,2-oxazines as Key Reaction, Eur. J. Org. Chem. 2011, 3210-3219(Impact factor 3.344)

 

33.    Hussain, J.; Hussain, H.; Ahmad, V. U.; Al-Harrasi. A.; and Badshah, A. Organotin(IV) Compounds of n-Propyl and isopropyl Glutarate: Their Synthesis and Spectral Characterization. Org. Comm., 2011, 5:1, 18-26.

 

34.    Hussain J, Rehman N, Khan AL, Sami F, Al-Harrasi A, Shinwari, Determination Of Macro And Micronutrients And Nutritional Prospects Of Six Vegetable Species Of Mardan, Pakistan, Pakistan Journal of Botany, 2011, 2829-2833. (Impact factor 0.913)

 

35.    Hussain J, Rehman N, Al-Harrasi A, Ali L, Ullah R, Mabood F, Hussain H, Ismail M, Nutritional prospects and mineral compositions of selected vegetables from Dhoda sharif – Kohat, Journal of Medicinal Plants Research, 2011, 5, 5509-65114. (Impact factor 0.54)

 

36.    Hussain J, Rehman N, Hussain H, Ali L, Al-Harrasi A, Ahmad V,  Nepethalates A and B: Two New Phthalate Derivatives from Nepeta clarkei, Helvitica Chemica Acta 2011, 94, 2106-2110. (Impact factor 1.22)

 

37.    Hussain J, Rehman N, Hussain H, Ali L, Mohammad FV, Al-Harrasi A, Ahmad VA, Two New Phthalate Derivatives from Nepeta clarkei (Labiatae), Asian Journal of Natural products 2011, 14, 22-26. (Impact factor 3.28)

 

38.    Hidayat Hussain, Javid Hussain, Ahmed Al-Harrasi, Chemistry and Biology of Genus Vismia, Pharmaceutical Biology, 2011, 1448-1462. (Impact factor 1.23)

 

39.    Al-Harrasi A, Al-Rawahi A, Hussain J, Rehman N, Ali L, Proximate Analysis of the Resins and Leaves of Boswellia sacra, Journal of Medicinal Plant Research, 2011, 6, 3098-3104. (Impact factor 0.54)

 

40.    Hussain, H.; Hussain, J.; Al-Harassi, A. (2011) Chemistry and Biology of    Bicoumarins. Tetrahedron, 68, 2553-2578. (Impact factor 2.899)

 

41.    Al-Harrasi, A.; Reissig, H-U. b-Alkoxy-g-Amino Aldehydes by Internal Redox Ring Cleavage of Carbohydrate Derived 1,2-Oxazines and Preparation of Heterocycles with Aminopolyol Side Chain, Synthesis 2011, 109-118. (Impact factor 2.54)

 

42.    Dekaris V, Pulz R, Al-Harrasi A, Lentz D, Reissig H, Stereoselective Syntheses of Aza, Amino and Imino Sugar Derivatives by Hydroboration of 3,6-Dihydro-2H-1,2-oxazines as Key Reaction, Eur. J. Org. Chem. 2011, 3210-3219. (Impact factor 3.344)

 

43.    Abu-Shanab,  Fathi A., Sayed A. S. Mousa, Eshak, E. A.; Al-Harrasi, A.Dimethylformamide Dimethyl Acetal (DMFDMA) in Heterocyclic Synthesis: Synthesis of Polysubstituted Pyridines, Pyrimidines, Pyridazine and Their Fused Derivatives, International Journal of Organic Chemistry. 2011, 1, 207-214. (Impact factor 0.54)

 

44.    Al-Harrasi, A.; Reissig, H-U. b-Alkoxy-g-Amino Aldehydes by Internal Redox Ring Cleavage of Carbohydrate Derived 1,2-Oxazines and Preparation of Heterocycles with Aminopolyol Side Chain, Synthesis 2011, 109-118. (Impact factor 2.54)

 

45.    Ismail YA, Martínez JG, Al Harrasi A, Kim SJ, Otero TF, Polypyrrol/Chitosan Hydrogel Hybrid Micro Fiber As Sensing Artificial Muscle, Electroective Polymer Actuators and Devices, Proc. of SPIE, vol 7976, 79761 L1 –L12 (2011).

 

46.    Ismail YA, Martínez JG, Al Harrasi A, Kim SJ, Otero TF, Sensing characteristics of a  conducting polymer/hydrogel hybrid microfiber artificial muscle, Sensors and Actuators B Chemical , 2011, DOI. 10.1016/j.snb.2011.09.044 (Impact factor 3.668)

 

47.    Hussain, H.; Hussain, J.; Al-Harassi, A. (2011) Chemistry and Biology of    Bicoumarins. Tetrahedron, 68, 2553-2578. (Impact factor 2.899)

 

48.    Hussain, H.; Hussain, J.; Al-Harassi, A.; Khan, Z. (2011) Chemistry and Biology of Genus Lantana. Pakistan Journal Botany., 54, 51-62. (Impact factor 0.921)

 

49.    Ng’ang’a, M. M.; Hussain, H.; Chhabra, S.; Langat-Thoruwa, C.; Riaz, M.; Hussain, J.; Al-Harrasi, A.; Krohn, K. (2011) Eucleanal: One new naphthalene derivative from Euclea divinorum. Nat. Prod. Commun., 7, 193-194. (Impact factor 1.42)

 

50.    Hussain J, Ullah R, Khan A, Mabood F, Shah MR, Al-Harrasi A, Gilani AH,  Antispasmodic and Ca++ antagonist potential of marrubiin, a labdane type diterpene from Phlomis bracteosa, Journal of Pharmacy Research 2011,4(1), 178-180.

 

Year 2010

 

51.    Al-Harrasi, A.; Fischer, S.; Zimmer, R.; Reissig, H-U. Ring Enlargement of Carbohydrate-Derived 1,2-Oxazines to Enantiopure 5-Bromo-1,2-oxazepines and Subsequent Palladium-Catalyzed Reactions, Synthesis 2010,  304-341. (Impact factor 2.54)

 

52.    Al-Harrasi, A.; Fischer, S.; Zimmer, R.; Reissig, H-U. Ring Enlargement of Carbohydrate-Derived 1,2-Oxazines to Enantiopure 5-Bromo-1,2-oxazepines and Subsequent Palladium-Catalyzed Reactions, Synthesis 2010,  304-341. (Impact factor 2.54)

 

Year 2009

 

53.    Pfrengle, F.; Al-Harrasi, A.;  Brüdgam, I.; Reißig, H.-U. Unusual Enantiopure Heterocyclic Skeletons via Lewis Acid Promoted Rearrangements of 1,3-Dioxolanyl-Substituted 1,2-Oxazines , Eur. J. Org. Chem. 2009, 282-291. (Impact factor 3.344)

 

54.    Al-Harrasi, A.; Pfrengle, F.; Prisyazhnyuk, V.; Yekta, S.; Koos, P.; Reissig, H.-U. Enantiopure Aminopyrans by a Lewis Acid Promoted Rearrangement of 1,2-Oxazines: Versatile Building Blocks for Oligosaccharide and Sugar Amino Acid Mimetics, Chemistry A European Journal  2009, 15, 11632 – 11641. (Impact factor 5.183)

 

55.    Pfrengle, F.; Al-Harrasi, A.;  Brüdgam, I.; Reißig, H.-U. Unusual Enantiopure Heterocyclic Skeletons via Lewis Acid Promoted Rearrangements of 1,3-Dioxolanyl-Substituted 1,2-Oxazines , Eur. J. Org. Chem. 2009, 282-291. (Impact factor 3.344)

 

56.    Al-Harrasi, A.; Pfrengle, F.; Prisyazhnyuk, V.; Yekta, S.; Koos, P.; Reissig, H.-U. Enantiopure Aminopyrans by a Lewis Acid Promoted Rearrangement of 1,2-Oxazines: Versatile Building Blocks for Oligosaccharide and Sugar Amino Acid Mimetics, Chemistry A European Journal  2009, 15, 11632 – 11641. (Impact factor 5.183)

 

Year 2008

 

57.    Abu-Shanab,  Fathi A., Al-Harrasi, A.;  Sayed A. S. Mousa, Synthesis of Diaryl-piperazine-2,6-dione: New Behavior of  N,N-Dimethylformamide dimethyl acetal (DMFDMA), Synth. Comm. 2008, 38, 375-382. (Impact factor 1.061)

 

58.    Hýrošová, E.; Fišera, L.; Medvecký M.; Reissig H.-U.; Al-Harrasi A.;  Koóš, M. From Sugras to Modeified Nucleosides, Arkivoc 2008, IX, 122-142. (Impact factor 1.042)

 

59.    Al-Harrasi, A.; Al-Saidi, S. Phytochemical Analysis of the Essential Oil from Botanically Certified Oleogum Resin of Boswellia sacra (Omani Luban), Molecules 2008, 13, 2181-2189. (Impact factor 2.68)

 

60.    Bressel, B.; Al-Harrasi, A.; Egart, B.; Pulz, R.; Reißig, H.-U.; Brüdgam, I. Acid Induced and Reductive Transformations of Enantiopure 3,6-Dihydro-2H-1,2-oxazines-Synthesis of Dideoxyamino Carbohydrate Derivatives, Eur. J. Org. Chem. 2008, 667-474. (Impact factor 3.344)

 

Year 2007

 

61.    Al-Harrasi, A.; Reißig, H.-U. [3+3] Cycloaddition Approach to the Synthesis of Substituted Pyrans and Oxepanes, Synfacts 2007, 296-297(Impact factor 2.54)

 

62.    Pfrengle F., Al-Harrasi, A.;  Reißig, H.-U. Lewis Acid Promoted Rearrangements of 1,3-Dioxolanyl-Substituted 1,2-Oxazines into Novel Products with 1,3,6-Trioxa-7-azacyclopenta[cd]indene Skeletones, Synlett 2006, 3498-3500. (Impact factor 2.64)

 

Year 2005

 

63.    Helms, M.; Schade, W.; Pulz, R.; Watanabe, T.; Al-Harrasi, A.; Fisera, L.; Hlobilová, I.; Zahn, G.; Reissig, H.-U. Stereodivergent Syntheses of Highly Substituted Enantiopure 4-Alkoxy-3,6-dihydro-2H-1,2-oxazines by Addition of Lithiated Alkoxyallenes to Carbohydrate-Derived Aldonitrones, Eur. J. Org. Chem. 2005, 1003-1019. (Impact factor 3.344)

 

64.    Al-Harrasi, A.; Reißig, H.-U. Synthese neuartiger enantiomerenreiner Kohlenhydratmimetika durch Lewis-Säure-induzierte Umlagerung von 1,3-dioxolanyl-substitutierten 3,6-Dihydro-2H-1,2-oxazinen, Angew. Chem. 2005, 117, 6383-6387. (Impact factor 13.74)

 

65.    Al-Harrasi, A.; Reißig, H.-U. Synthesis of Novel Enantiopure Carbohydrate Mimetics by Lewis Acid Catalyzed Rearrangement of 1,3-Dioxolanyl Substituted 3,6-Dihydro-2H-1,2-oxazines, Angew. Chem. Int. Ed. 2005, 44, 6227-6231. (Impact factor 13.74)

 

66.    Al-Harrasi, A.; Reißig, H.-U. Synthesis of Enantiopure Functionalized b-Alkoxy g-Amino Aldehydes by a New Internal Redox Ring Cleavage of Carbohydrate Derived 1,2-Oxazines, Synlett 2005, 1152-1154. (Impact factor 2.64)

 

67.    Al-Harrasi, A.; Reißig, H.-U. Ring Enlargement of Enantiopure 1,2-Oxazepine Derivatives and Their Palladium-Catalyzed Couplings,  Synlett 2005, 2376-2378. (Impact factor 2.64)

 

68.    Al-Harrasi, A.; Reißig, H.-U. Crystal structure of 1R ,5S ,8R ,9S -8-azidomethyl-2-benzyl-6,6-dimethyl-3,7-dioxa-2-aza-bicyclo[3.3.1]nonan-9-ol, C16H22N4 O3, Zeitschrift für Kristallographie - New Crystal Structures 2005, 599-600. (Impact factor 0.103)

 

69.    Al-Harrasi, A.; Reißig, H.-U. Crystal structure of  3S,4S,5R,6S,7R-5-Amino-6-tert-butyldimethylsiloxy-7-tert-butyldimethylsiloxymethyl-3-hydroxymethyl-2,2-dimethyloxepan-4-ol, Zeitschrift für Kristallographie - New Crystal Structures 2005, 131-132. (Impact factor 0.103)

 

70.    Al-Harrasi, A.; Reißig, H.-U. Crystal structure of 3S,4'S,6'S-2-Benzyl-3-[(tert-butyldimethylsiloxy)-(2',2'-dimethyl-1,3-dioxolan-4'-yl)-6'-methyl]-4-[2-(trimethylsilyl)ethoxy]-3,6-dihydro-2H-1,2-oxazine, Zeitschrift für Kristallographie - New Crystal Structures 2005,12-13. (Impact 0.103)

 

71.    Al-Harrasi, A.; Reißig, H.-U. Synthese neuartiger enantiomerenreiner Kohlenhydratmimetika durch Lewis-Säure-induzierte Umlagerung von 1,3-dioxolanyl-substitutierten 3,6-Dihydro-2H-1,2-oxazinen, Angew. Chem. 2005, 117, 6383-6387. (Impact factor 13.74)

 

72.    Al-Harrasi, A.; Reißig, H.-U. Synthesis of Novel Enantiopure Carbohydrate Mimetics by Lewis Acid Catalyzed Rearrangement of 1,3-Dioxolanyl Substituted 3,6-Dihydro-2H-1,2-oxazines, Angew. Chem. Int. Ed. 2005, 44, 6227-6231. (Impact factor 13.74)

 

73.    Helms, M.; Schade, W.; Pulz, R.; Watanabe, T.; Al-Harrasi, A.; Fisera, L.; Hlobilová, I.; Zahn, G.; Reissig, H.-U. Stereodivergent Syntheses of Highly Substituted Enantiopure 4-Alkoxy-3,6-dihydro-2H-1,2-oxazines by Addition of Lithiated Alkoxyallenes to Carbohydrate-Derived Aldonitrones, Eur. J. Org. Chem. 2005, 1003-1019. (Impact factor 3.344)

 

Year 2002

 

74.    Pulz, R.; Al-Harrasi, A.; Reissig, H.-U. Acid Promoted Syntheses of New Enantiopure Amino Sugar Derivatives from 3,6-Dihydro-2H-1,2-oxazines  Synlett 2002, 817-819. (Impact factor 2.655)

 

75.    Pulz, R.; Al-Harrasi, A.; Reissig, H.-U. New Polyhydroxylated Pyrrolidines Derived from Enantiopure 3,6-Dihydro-2H-1,2-oxazines,  Org. Lett. 2002, 4, 2353-2355. (Impact factor 6.184)

 

76.    Hisham, A.; Al-Harrasi, A.; Shuaily, W.; Echigo, S.; Fujimoto,Y. Cardiopetalolactone: A Novel Styryllactone from Goniothalamus cardiopetalus, Tetrahedron 2000, 56, 9985-9989. (Impact factor 2.899)

 

Submitted

 

77.    Hussain H.; Al-Harrasi A.; Green IR.; Ahmed I.; meta-Chloroperbenzoic acid (m-CPBA): A Versatile Reagent in Organic Synthesis, Chemical Reviews, 2013, submitted.

 

78.    Khan AL.; Kim MJ.; Hussain J.; Al-Harrasi A.; Waqas M.; Al-Rawahi A.; Al-Hosni K .; Lee IJ.; Newly isolated strains of fungal endophytes Aspergillus caespitosus LK12 and Phoma medicaginis LK13 produce gibberellins, Trees, 2013, submitted.  

 

79.    Hussain J, Rehman N, Ali L, Al-Harrasi A, Khan N, Shinwari ZK, Nutritional Assessment and Mineral Composition of Some Selected Vegetables of Hangu, KP, Pakistan, Journal of Asian Science & Technology, 2013, submitted.

 

80.    Al-Harrasi A, Hussain H, Hussain J, Al-Rawahi A, Structure, Bio-activity and Chemical Synthesis of Boswellic Acids and Other Terpenoids in Genus Boswellia, Chemical Reviews, 2013, accepted.

 

81.    Hussain, J.; Rehman, N.; Hussain, H.; Al-Harrasi, A.; Ali, L.; Ahmad, M,; Mehjabeen. (2013) Analgesic, Anti-inflammatory, and CNS depressant Activities of Nepethale B. Phytotheraphy Research (Submitted).

 

82.    Hussain, J.; Begum, N.; Rehman, N.; Hussain, H.; Al-Harrasi, A.; Abbas, G.; Ahmad, S. (2013) Lipid peroxidation, antiglycation, cytotoxic, phytotoxic, antioxidant, antiplatelet and antimicrobial activities of Ajuga bracteosa. International Journal of Pharmacy and Pharmaceutical Sciences (Submitted).

 

83.    Al-Harrasi A, Al-Maawali S, Al-Sibani M, Rehman N, Al-Azri A, Al-Rawahi A, Hussain J, Ali L, First Quantitative Analysis of Essential and Trace Elements in Omani Frankincense (Boswellia sacra) Resins and Leaves Using ICP-AES, Spectrochemica Acta B 2013, submitted.

 

84.    Hussain, J.; Rehman, N.; Hussain, H.; Ali, L.; Al-Harrasi, A.; Shinwari, Z.H. Nutritional Assessment and Mineral Composition of Some Selected Vegetables of Pakistan. Czech Journal of Food Science (Submitted)

 

85.    Al-Harrasi, A.; Al-Rawahi, A.; Hussain, J.; Ali, L.; Hussain, H.; Rehman, N.; Ahmad, M.; Mehjabeen. Antinociceptive effects of the oils, crude extract, and various fractions of the Omani Frankincense obtained from Boswellia sacra. Journal of Ethnopharmacology (submitted).

 

86.    Al-Harrasi A, Al-Rawahi A, Al-Sabahi J, Hussain J, Al-Harrasi R, El-Nagerabi S, Chemical Compositions of Six Grades of Omani Olibanum Resins, Leaves and Pyrolysis Products and in vitro Antifungal Activity of Boswellia sacra Resin Against Toxigenic Aspergillus flavus, Flavour and Fragrance, submitted.

 

87.    Al-Harrasi A, Al-Rawahi A, Al-Sabahi A, Hussain J, Al-Harrasi R, Physico-Chemical Properties and Volatile Compositions of Date palm (Phoenix dactylifera L) Fruits and Seeds at Different Maturation Stages, Journal of Food Science, submitted.

 

88.    Hussain J, Rehman N, Ullah R, Muhammad R, Al-Harrasi  A, Arshad T. Nutritional Assessment and Chemical Composition of Some Selected Vegetables from Dhoda Sharif – Kohat. Pakistan Journal of Botany (Submitted)

 

89.    Hussain J, Rehman N, Ullah R, Al-Harrasi  A, Wali F. Antiglycation, cytotoxic, phytotoxic, insecticidal and antimicrobial activities of extracts of Nepeta clarkei. Journal of Pharmacy Research (submitted)

 

90.    Samina Ali, Syed TasleemHussain Shah, Liaqat Ali, Javid Hussain, Ahmed Al-Harrasi, and Tania ShamimRizvi, Antioxidant Activities of one New and four known Flavonoids from Nepetafloccosa, Chemistry and Biodiversity,Submitted (2013).

 

91.    Muhammad Kamran, Abdul Latif Khan, Liaqat Ali, In-Jung Lee, Ahmed Al-Harrasi, Yoon Ha Kim, JavidHussain, and Muhammad Waqas, Hydroquinone from plant-derived smoke can cue seed germination, Molecule, Submitted (2013).

 

92.    Hidayat Hussain, Ahmed Al-Harrasi, Ghulam Abbasa, Najeeb Ur Rehmana, Amin Badshahd, Afzal Shahd, Fazal Mabooda, Muhammad Saleeme, Karsten Krohna, Barbara Schulzf, Iftikhar Alig, Antimicrobial Activities of Quinoline-5,8-dione and Hydroxynaphthoquinone Derivatives, Arabian Journal of Chemistry, 2013, accepted.

 

93.    H. Hussain, A. Zahoor, I. Siddiqui, Ahmed Al-Harrasi, G. Abbas, N. Rehman, A. Badshah, A. Shah, M. Saleem, K. Krohn, B. Schulz (2013). Phytochemical and Antimicrobial Activity of Derris scandens. Records of Natural Products (submitted).

 

94.    H. Hussain, I. Ahmed, Ahmed Al-Harrasi, G. Abbas, N. Rehman, A. Badshah, A. Shah, M. Saleem, S. Draeger, I. Ali, B. Schulz, K. Krohn (2013). Meliodentalin A and B: Two Antimicrobial New Dihydroisocumarins From Endophytic Fungus Meliotus dentatus. Bioorganic Chemistry (submitted).

 

95.    H. Hussain, F. Jabeen, Ahmed Al-Harrasi, M. Ahmad, F. Mabood, A. Zahoor, G. Abbas, N. Rehman, A. Badshah, A. Shah, M. Saleem, B. Schulz, K. Krohn (2013). Microdiplanol: A New m-Anisaldehyde derivative from the Endophytic Fungus Microdiplodia sp.Records of Natural Products (submitted).

 

96.    H. Hussain, Ahmed Al-Harrasi, S. Qin, G. Abbas, N. Rehman, A. Badshah, A. Shah, M. Saleem, B. Schulz, K. Krohn (2013). Kabatinane A: A New 24-methylcholestanol derivative from the Endophytic Fungus Kabatina sp. Records of Natural Products (submitted).

 

8.3  ChemInform Abstracts

 

1. Robert Pulz, Ahmed Al-Harrasi, Hans-Ulrich Reissig, New Polyhydroxylated Pyrrolidines Derived from Enantiopure 3,6-Dihydro2H-1,2-oxazines, ChemInform 01/2010; 33(48).

 

2. Ahmed Al-Harrasi, Sebastian Fischer, Reinhold Zimmer, Hans-Ulrich Reissig, Ring Enlargement of Carbohydrate-Derived 1,2-Oxazines to Enantiopure 5-Bromo-1,2-oxazepines and Subsequent Palladium-Catalyzed Reactions ChemInform 01/2010; 41(21).

 

3. Robert Pulz, Ahmed Al-Harrasi, Hans-Ullrich Reissig, Acid-Promoted Syntheses of New Enantiopure Amino Sugar Derivatives from 3,6-Dihydro2H-1,2-oxazines, ChemInform 01/2010; 33(37).

 

 

4. Eva Hyrosova, Lubor Fisera, Michal Medvecky, Hans-Ulrich Reissig, Ahmed Al-Harrasi, Miroslav Koos, From Sugars to Modified Nucleosides, ChemInform 01/2009; 40(34).

 

8.4  Conference Proceedings and Invited Lectures

 

1.      Ahmed Al-Harrasi, Synthesis of Highly Functionalised Enantiopure Heterocycles from  1,2-Oxazines (Track: Stereoselective Synthesis of Bioactive Compounds), 3rd International Conference on Drug Discovery & Therapy,  Dubai, UAE, February 7th to 10th, 2011.

 

2.      Ahmed Al-Harrasi, 1,3-dioxolanyl-substituted 1,2-Oxazines: Novel Precursors for Synthesis of Highly Functionalised Enantiopure Heterocycles, The 12th Ibn Sina International Conference on Pure and Applied Heterocyclic Chemistry, Luxor-Egypt, 14-17 February 2011

 

3.      Fathi A. Abu-Shanab, Sayed A. S. Mousa, E. A. Eshak, Ahmed Al-Harrasi, Ahmed Z. Sayed,  New Routes for the Synthesis of Polysubstituted Pyridines, Pyrimidines, Pyridazine and their Fused Derivatives Using imethylformamide Dimethyl Acetal (DMFDMA), The 12th Ibn Sina International Conference on Pure and  Applied Heterocyclic Chemistry, Luxor-Egypt, 14-17 February 2011

 

4.      Ahmed Al-Harrasi, Nitrogen Heterocycles from 1,2-Oxazines, 11th Annual Florida Heterocyclic and Synthetic IUPAC-Sponsored Conference, USA, 6th -10th March 2010.    

 

5.      Ahmed Al-Harrasi, Nitrogen Heterocylcles and More from 1,2-Oxazines, Fulbright OLP Invited Speaker, University of Wisconsin, USA, 5th – 7th February 2009.

 

6.      Ahmed Al-Harrasi, New Transofrmations from 1,2-Oxazines, Cornell University (Department of Chemistry and chemical Biology), USA, December 2009.

 

7.      Ahmed Al-Harrasi, Sustainability in the Organic Chemistry Lab Course, UNESCO World Conference on Education for Sustainable Development, Bonn, 1st-4th April 2009, Germany.

 

8.      Ahmed Al-Harrasi, New Transformations from1,2-Oxazines:  Synthesis of Highly Functionalised Enantiopure Heterocycles, University of Wisconsin Oshkosh, USA, February 2009.

 

9.      Ahmed Al-Harrasi, Synthesis of Highly Functionalised Enantiopure Heterocycles, Cornell University, USA, December 2008.

 

10.  Ahmed Al-Harrasi, 1,3-dioxolanyl-substituted 1,2-Oxazines: Novel Precursors for Synthesis of Highly Functionalised Enantiopure Heterocycles, Kuwait 01/03/2008-08/03 2008.

11.  Ahmed Al-Harrasi, The Date Palm Fruit, Arab Naturals: Complementary Medicine and Healthcare, Abu Dhabi, 2007.

 

12.  Ahmed Al-Harrasi, A Perfect Date, International Conference on Ayruved and Complementary System of Medicine, Singapore, 2007

 

13.  Ahmed Al-Harrasi, Diastereoselective Synthesis of Carbohydrate Mimetics, Biannual Conference of Chemistry, University of Cairo, Egypt, 05/03/2006-08/03/2006.

 

8.5  Posters and Abstracts

 

14.  Ahmed Al-Harrasi, Diastereoselective Synthesis of Carbohydrate Mimetics, Biannual Conference of Chemistry 05/03/2006-08/03/2006, University of Cairo, Egypt.

 

15.  Ahmed Al-Harrasi, 1,3-dioxolanyl-substituted 1,2-Oxazines: Novel Precursors for Synthesis of Highly Functionalised Enantiopure Heterocycles, Kuwait 01/03/2008-08/03 2008.    

 

16.  Ahmed Al-Harrasi, A Perfect Date, International Conference on Ayruved and Complementary System of Medicine, Singapore, 2007.

 

17.  Ahmed Al-Harrasi, The Fruit of Date Palm (Phoenix dactylifera): Its Use as a Promising Future Best Food, Abu Dhabi, UAE.

 

18.  Ahmed Al-Harrasi, COMSTECH-TWAS Young Scientists Conference at the Interface of Chemistry and Biology, Islamabad, Pakistan, 2007. 

 

19.  Ahmed Al-Harrasi, Khwarizmi International Award, Tehran, Iran.

 

20.  Ahmed Al-Harrasi and Hans-Ulrich Reissig, Synthesis of Carbohydrate Mimetics, Annual Conference of Carboyhdrates, Berlin, October 2005, Germany.

 

21.  Ahmed Al-Harrasi and Hans-Ulrich Reissig, Reactions of 1,2-oxazines: Internal  Redox Ring Cleavage and Solvolytic Ring Enlargement, Tag der Chemie 2005, Berlin, July 2005, Germany.

 

22.  Vladimir Prisyazhnyuk, Ahmed Al-Harrasi, Hans-Ulrich Reissig, Reactions of 1,2-oxazines: Synthesis of highly functionalized enantiopure amino sugars and sugar amino acids, 11th Blue Danube Symposium on Heterocyclic Chemistry, September 2005, Czech Republic.

 

23.  Ahmed Al-Harrasi and Hans-Ulrich Reissig, Reactions of Lithiated Allenes with Chiral Nitrones: Synthesis of Amino Sugars and Pyrrolidine Derivatives, Tag der Chemie 2004, Potsdam, July 2004, Germany.

 

24.  Ahmed Al-Harrasi and Hans-Ulrich Reissig, Reactions of Lithiated Allenes with Chiral Nitrones: Synthesis of Highly Functionalized Sugar Derivatives, Jahresstagung Chemie 2003 (GDCh), Munich, 6-11 October 2003, Germany.

 

25.  Ahmed Al-Harrasi, Hans-Ulrich Reissig, Greg Roos, Allenes and allenamides as novel precursors in organic synthesis, SQU Open Day, April 2003.

 

9. WORKSHOPS

 

1.      The Grant Writing & Research Management Symposium, January 24-26, 2011, Organized by Research Council, University of Nizwa. Panel Superevisor.

 

2.      Biodiversity: Efforts in Conservation and Sustainable Utilization of Oman’s Genetic Resources, 10-12 January 2011, Organized by Research Council in Sultan Qaboos University.

 

3.      His Majesty’s Sultan Qaboos bin Said Scientific Chairs, Sultan Qaboos University, 01-03 March 2010, Organized by Research Council.

 

4.      INCONET-GCC roundtable workshop, Muscat Intercontinental, 06-07 December 2010. Organized by Research Council.

 

5.      Date Palm Exhibition, Abu Dhabi, 22-24 November 2010.

 

 

 

10. CURRENT RESEARCH ACTIVITIES

 

10.1 My Research Vision

 

Our chair involves a group of scientists working at the interface of several disciplines, striving to discover lead compounds as potential future drugs from medicinal plants and marine natural products as well as from their synthetic analogs.

 

Oman is very rich country of medicinal plants and herbs which provide very rich environment for investigating numerous species growing in the deserts of Oman. Furthermore, Omani traditional medicines are valuable natural heritages waiting to be investigated by modern science.

 

Natural Products Chemistry focuses on the discovery of new compounds with biological activities which may be of medical importance and which are produced by plants, animals or other organisms. Leads for new biologically active compounds come from knowledge of use of an organism in traditional medicine (ethnobotany), folkloric reputation of use, or from random screens. Extracts are tested against biological and biochemical assays and the active fractions purified to find the active compound(s). Structural characterization of the compounds by spectroscopy and related analytical methods completes the preliminary investigations which may lead to new therapeutic drugs.

 

Moreover, the science of Organic Synthesis is aimed towards developing new ways to generate precious entities more efficiently and with specific architectures. Many recent efforts have targeted the development of new environmentally friendly methods that improve the efficiency in which we can target the enantiopure compounds.

Despite the dramatic successes of organic synthesis in the last few decades, there still remains much room for improvements on several levels. For example, one cannot always efficiently synthesize everything that is desired, and syntheses of highly complex molecules are time consuming. It is clear that more powerful and general methods of synthesis are needed.

Thus, the specific aim of our research is geared towards the development of new methods for the diastereoselective synthesis of organic molecules. This is a formidable challenge, since atoms within a molecule have the same connectivity but vary only in their three-dimensional relationship. Our primary goal is the design and development of new tools (reagents and ligands) that take advantage of the entire periodic table of elements to achieve a given transformation with complete stereocontrol. For example, we are exploring new efficient routes to carbohydrate mimetics, amino polyols, amino, imino and azasugars and sugar amino acids and polyhydroxylated pyrrolidines. Finally, the synthesis of complex natural products is pursued, since this is the ultimate ground to test the efficiency of new synthetic methodologies.

 

 

 

 

 

 

10.2  Areas of My Research Interests and Projects

 

10.2.1 Chemical Study of Boswellia sacra Resin Fumes

 

Isolation & Structure Elucidation

 

Frankincense is one of the most evocative expressions of Oman’s vibrant heritage and culture. Dhofar region, which is situated in the southern part of Oman, is the world's leading source of frankincense. Since most of the Omani people are using frankincense for fumes generation, exploring the nature and composition of these fumes would provide a significant contribution to completing our knowledge of this traditional precious plant resin.  The pharmacological activities of frankincense, in various forms including as a crude extract, as the distilled essential oil and also of specific isolated compounds will be investigated.

 

Discoveries

 

We are discovering lead compounds from Omani frankincense resins and test their biological activities both in vitro and in vivo. Below are some of the isolated and characterized compounds from Omani frankincense (Boswellia scara) in my research group. All of these compounds (except 3-7 & 12) have been isolated for the first time from Boswellia sacra.

Text Box: 1 R1, R4 = H, R2 = OH, R3 = COOH, R5 = OEt
2 R1, R5 = H, R2 = O, R3 = CH3, R4 = OH
3 R1, R4, R5 = H, R2 = OH, R3 = COOH
4 R1, R4 = H, R2 = OH, R3 = COOH, R5 = O
5 R1, R4, R5 = H, R2 = OAc, R3 = COOH
6 R1, R4, = H, R2 = OAc, R3 = COOH, R5 = O
7 R1, R2 = OH, R3 = COOH, R4, R5 = H

11 R1 = OH, R2 = CH3, R3 = O

12 R1 = OH, R2 = COOH, R3 = H

13 R1 = OH, R2 = CH3, R3 = H

14 R1 = O, R2 = CH3, R3 = OH

 

Text Box: 8   R1 = OAc, R2 = COOH, R3 = H
9   R1 = OH, R2 = CH2OH, R3 = H
10 R1 = O, R2 = COOH, R3 = O

 

 

Figure 1: Structures of compounds 1-14 isolated  from Frankincense (Boswellia sacra)

 

Enhancement of the Most Active Anti-Cancer Boswellic Acid (AKBA) in Boswellia Sacra Extract

 

Boswellic acids are very fascinating compounds and there is an increasing demand for these  substances for pharmaceutical and medicinal studies. Our laboratory has been very busy in isolating these compounds from the Omani frankincense (Boswellia sacra). Unfortunately, the concentration of the most active boswellic acid, 3-O-acetyl-11-oxo-β-boswellic acid AKBA (3), in extracts from Boswellia resins is in the range of 0.1_3% and it is therefore very difficult and time consuming to isolate large amounts of this compound. Here, we wish to follow a chemical modification strategy for the large-scale synthesis of AKBA (3) and the other boswellic acids. The big-scale synthesis of AKBA will allow further modifications thereby increasing the possibilities of better activities.

 

Unfortunately, the concentration of the most active boswellic acid, 3-O-acetyl-11-oxo-β-boswellic acid AKBA (3), in extracts from Boswellia resins is in the range of 0.1_3% and it is therefore very difficult and time consuming to isolate large amounts of this compound. Via tow-steps approach, large-scale synthesis of AKBA (3) and the other boswellic acids is a achieved.  

 

                           

Using the above scheme, the percentage of AKBA will be raised from 0.1% to about 35%. The following focus approach illustrates this enhancement process.

 

 

Likewise, the beta-boswellic acid (BA) can be enhanced applying similar policy, first by deacetylation followed by Wolf-Kishner reaction to convert the ketone moiety into methylene.

 

Pyrolysis of Frankincense resin

 

One of the challenging research topic is the investigation of the pyrolysate of  frankincense resin. We have developed a technique in which the incense is captured and was turned into an analyzable material. After extraction and purification we are studying the chemical constituents of the smoke. This shall also enable us to study the mechanisms associated with possible thermal rearrangements.

 

 

10.2.2 Asymmetric Synthesis

 

My research interests on this area focus mainly on the synthesis of carbohydrate mimetics amino polyols, amino, imino and azasugars and sugar amino acids and polyhydroxylated pyrrolidines via newly self developed methodologies. Some of theses novel compounds are tested with collaboration with college of medicine (Free University of Berlin) and showed to be potent glycosidase and fucosidase inhibitors. The novel synthetic methods that we used made it possible to prepare compounds in an enantiopure manner. These methods involve shorter synthetic pathways by introducing up to 4 stereogenic centres in one step. These synthetic pathways were successfully employed in pilot plant synthesis. In this Project, I have achieved so far 230 new products and I have developed 3 completely new methods to prepare carbohydrate mimetics of 6, 7 and 8 membered rings.

 

 

 

10.2.3 Synthesis of isotopically-labeled thiamin pyrophosphate

 

This project involves the synthesis of thiamin analogs. These will be used as mechanistic probes for thiamin biosynthetic and thiamin-utilizing enzymes as well as for the selective labeling of thiamin-utilizing enzymes in various proteomes.

 

 

10.3   Major Achievements

 

10.3.1 Founder of UoN Chair of Oman’s Medicinal Plants and Marine Natural Products with a budget = 9,748,992.36 USD

 

The University of Nizwa (UoN) envisioned this chair and drew necessary implementation plans that emphasized dynamic sequential implementations and both internal as well as external funding. As a consequence the UoN built and furnished required research facilities and labs, recruited highly qualified researchers and capitalized effectively on its international networks.

 

The University of Nizwa has created this chair as a vital vehicle in delivering its research strategy’s objectives among other means including research teams and research centers.  This chair shall focus on medicinal plants and marine natural products. Accordingly, it has been named University of Nizwa Chair on Oman’s Medicinal Plants and Marine Natural Products.

 

Indeed it comes as a direct response to the research strategy of the Sultanate of Oman that aims at creating an innovation culture where capacities are being built, collaboration and networking among researchers, scholars and institutions are being forged, and where innovation outcomes are transformed toward social economic growth. This new Chair embodies all those noble objectives.

 

This five-year programme is set to further build on Omani excellence in the chemistry, pharmacognesy and pharmacology of medicinal plants and marine natural products of Oman. All of which are of immense economic potentials. No doubt, this chair will boost knowledge transfer, enhance Omani human resource building and strengthen scientific bridging between Oman and other countries. The chair shall cater to various needs of the country in basic as well as applied and specialized areas of natural products research and education related to the chair scope of activities.

 

Oman is endowed with rich biodiversity both marine and terrestrial that has acclimated to the arid climate. Its agro systems both traditional and conventional encompasses a wide range of crops including herbs, vegetables, fruits, grains and forges. Its mountains, villages, valleys and coastline are alive with indigenous plants, animals and species. This chair is pioneered by devoted researchers. Located at the University of Nizwa , our scientists enjoy tremendous opportunities of investigating numerous species growing in Jabel Al-Akhdar as well as other parts of Oman.

 

Under the umbrella of the UoN Chair of Oman’s Medicinal Plants and Marine Natural Products we are discovering lead compounds from medicinal plants as well as marine species of Oman by isolation through chromatographic techniques including CC and preparative HPLC followed by extensive spectroscopic analyses using 1D and 2D NMR, IR, MS and when possible through X-ray diffraction analysis. Our research activities also include microbiology, pharmacology and molecular biology research. We are also interested on drugs for cancer therapy. In addition we are involved on remediation of heavy metals contamination in Oman using extremophilic endophytes. Our recent research topic focuses on plant DNA barcoding.

 

10.3.1 National Chair in Materials Science and Metallurgy with a budget = 13,319,320.80 USD

 

This proposal for the creation of a Chair in Materials Science and Metallurgy at the University of Nizwa comes in response to the research strategy of the Sultanate of Oman that aims at creating an innovation culture where capacities are being built, collaboration and networking among researchers, scholars and institutions are being forged, and where innovation outcomes are transformed toward social economic growth. This new Chair embodies all those noble objectives. The creation of the Chair as a joint effort between the University of Nizwa and the University of Cambridge comes as an appreciation of His Majesty Sultan Qaboos bin Saeed endowed chair of Modern Arabic and His Majesty’s endowed chair of Abrahamic Faiths and Shared Values at University of Cambridge. This joint initiative by the University of Nizwa and the Department of Materials Science and Metallurgy at the University of Cambridge in the United Kingdom, as a five-year program, is set to build further on Omani excellence in the development of Extractive Metallurgy, Electrometallurgy, and Energy Materials and Devices. All these possess immense economic potential. No doubt, this new Chair will boost knowledge transfer, enhance Omani human resource building and strengthen scientific bridging between Oman and United Kingdom

 

11. LANGUAGES

 

Arabic: (mother tongue)

English: fluent in written and spoken English

German: fluent in written and spoken German

 

12. REFERNCES

 

1. Prof. Ahmed Al-Rawahi, Chancellor University of Nizwa

 

P.O. Box 941, Seeb Central Post, PC 111

Sultanate of Oman.

e-mail: ahmed@unizwa.edu.om

Fax: (968)-24- 543775

Phone: (968)- 24-543775

GSM: (968)- 99340264

 
2. Prof. Abdulaziz Al-Kindy, Vice Chancellor for Academic Affairs
University of Nizwa

Sultanate of Oman.

e-mail: alkindy@unizwa.edu.om

Fax: (968)-25446311

GSM: (968)- 99466026

 
3. Prof. Tadhg P. Begley tpb2@cornell.edu
 
Professor of Chemistry and Chemical Biology
Department of Chemistry
120 Baker Laboratory 
Cornell University
Ithaca
NY 14853
Tel: 607-255-7133
 

4. Prof. Hans-Ulrich Reissig Hans.Reissig@Chemie.FU-Berlin.De

 

Telephone: +49 30 838-55366

Fax: +49 30 838-55 367

Free University of Berlin

Institute of Organic Chemistry

Takustr. 3

D-14195 Berlin, Germany